Chiefly known as an architect practicing in Baltimore, MD, Edward H. Glidden was the son of William Pierce Glidden, founder of the Glidden Varnish Company. Against his father's wishes, he became an architect, studying in Paris from 1908 to 1912. He eventually made his way to Baltimore and established an office there. Chief among his works in Baltimore were the Homewood Apartments, Washington, Canterbury Hall and Tudor Hall Apartments.
At the time of his death Glidden was associated with Hobart Upjohn, who prepared his obituary for the AIA, for a competition for the new college buildings for Baltimore City College.
He joined the AIA in 1901.